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Abstract The convulsant alkaloid bicuculline continues to be investigated over 40 decades following the main publication of its action as an antagonist of receptors with the inhibitory neurotransmitter GABA. This historical perspective highlights key components of the invention of bicuculline as a GABA antagonist as well as the sustained desire Wit

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species, brings about quick plant necrosis and chlorosis, very like that of bipyridinium herbicides like paraquat [63]. Studies with isolated chloroplasts confirmed that its mode of action is strictly like bipyridiniums, diverting electrons from photosystem I to become lessened into a reactive radicle that subsequently generates superoxide radicle,

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